Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9127
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dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Morris, H. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Nauck, M. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Peptides, 1998; 19(6):1049-1053 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.issn | 1873-5169 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9127 | - |
dc.description.abstract | Glucagon-like peptide-1 (GLP-1) may play a role in regulating gastric emptying. The aim of this study was to determine the relationship between gastric emptying of glucose and plasma concentrations of GLP-1. Gastric emptying of 75 g of glucose dissolved in 350 ml of water was measured by the use of scintigraphy in 12 normal volunteers. Venous blood samples for measurement of GLP-1 were obtained immediately before and for 180 min after ingestion of glucose. Plasma GLP-1 rose rapidly from a baseline of 8.5 +/- 1.2 pmol/l to 14.3 +/- 1.3 pmol/l at 10 min (p = 0.024), with a peak of 19.2 +/- 3.0 pmol/l at 30 min (p = 0.0006) after the glucose drink. The rate of gastric emptying was inversely related to the early rise in GLP-1, e.g., the 50% emptying time was related to the change in GLP-1 from baseline at 10 min (r = 0.57; p < 0.05). We conclude that there is an inverse relationship between gastric emptying of glucose and plasma GLP-1. This observation is consistent with the concept that GLP-1 is a determinant of, rather than determined by, the rate of gastric emptying. | - |
dc.description.statementofresponsibility | Wishart, Judith M. ; Horowitz, Michael ; Morris, Howard A. ; Jones, Karen L. ; Nauck, Michael A. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.source.uri | http://dx.doi.org/10.1016/s0196-9781(98)00052-7 | - |
dc.subject | Humans | - |
dc.subject | Body Weight | - |
dc.subject | Glucagon | - |
dc.subject | Glucose | - |
dc.subject | Peptide Fragments | - |
dc.subject | Protein Precursors | - |
dc.subject | Body Mass Index | - |
dc.subject | Gastric Emptying | - |
dc.subject | Time Factors | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.title | Relation between gastric emptying of glucose and plasma concentrations of glucagon-like peptide-1 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0196-9781(98)00052-7 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Morris, H. [0000-0002-2745-3750] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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