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https://hdl.handle.net/2440/9127
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Type: | Journal article |
Title: | Relation between gastric emptying of glucose and plasma concentrations of glucagon-like peptide-1 |
Author: | Wishart, J. Horowitz, M. Morris, H. Jones, K. Nauck, M. |
Citation: | Peptides, 1998; 19(6):1049-1053 |
Publisher: | ELSEVIER SCIENCE INC |
Issue Date: | 1998 |
ISSN: | 0196-9781 1873-5169 |
Statement of Responsibility: | Wishart, Judith M. ; Horowitz, Michael ; Morris, Howard A. ; Jones, Karen L. ; Nauck, Michael A. |
Abstract: | Glucagon-like peptide-1 (GLP-1) may play a role in regulating gastric emptying. The aim of this study was to determine the relationship between gastric emptying of glucose and plasma concentrations of GLP-1. Gastric emptying of 75 g of glucose dissolved in 350 ml of water was measured by the use of scintigraphy in 12 normal volunteers. Venous blood samples for measurement of GLP-1 were obtained immediately before and for 180 min after ingestion of glucose. Plasma GLP-1 rose rapidly from a baseline of 8.5 +/- 1.2 pmol/l to 14.3 +/- 1.3 pmol/l at 10 min (p = 0.024), with a peak of 19.2 +/- 3.0 pmol/l at 30 min (p = 0.0006) after the glucose drink. The rate of gastric emptying was inversely related to the early rise in GLP-1, e.g., the 50% emptying time was related to the change in GLP-1 from baseline at 10 min (r = 0.57; p < 0.05). We conclude that there is an inverse relationship between gastric emptying of glucose and plasma GLP-1. This observation is consistent with the concept that GLP-1 is a determinant of, rather than determined by, the rate of gastric emptying. |
Keywords: | Humans Body Weight Glucagon Glucose Peptide Fragments Protein Precursors Body Mass Index Gastric Emptying Time Factors Adult Female Male Glucagon-Like Peptide 1 |
DOI: | 10.1016/S0196-9781(98)00052-7 |
Published version: | http://dx.doi.org/10.1016/s0196-9781(98)00052-7 |
Appears in Collections: | Aurora harvest Medicine publications |
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