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https://hdl.handle.net/2440/94022
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Type: | Journal article |
Title: | Silica microcapsules from diatoms as new carrier for delivery of therapeutics |
Author: | Aw, M. Simovic, S. Addai-Mensah, J. Losic, D. |
Citation: | Nanomedicine, 2011; 6(7):1159-1173 |
Publisher: | Future Medicine |
Issue Date: | 2011 |
ISSN: | 1743-5889 1748-6963 |
Statement of Responsibility: | Moom Sinn Aw, Spomenka Simovic, Jonas Addai-Mensah & Dusan Losic |
Abstract: | Aim: This study explores the use of natural silica-based porous material from diatoms, known as diatomaceous earth, as a drug carrier of therapeutics for implant- and oral-delivery applications. Materials & Methods: To prove this concept, two drugs models were used and investigated: a hydrophobic (indomethacin) and hydrophilic (gentamicin). Results & Discussion: Results show the effectiveness of diatom microcapsules for drug-delivery application, showing 14–22 wt% drug loading capacity and sustained drug release over 2 weeks. Two steps in the drug release from diatom structures were observed: the first, rapid release (over 6 h is attributed to the surface deposited drug) and the second, slow and sustained release over 2 weeks with zero order kinetics. Conclusion: These results confirm that natural material based on diatom silica can be successfully applied as a drug carrier for both oral and implant drug-delivery applications, offering considerable potential to replace existing synthetic nanomaterials. |
Keywords: | Diatoms Silicon Dioxide Indomethacin Gentamicins Anti-Inflammatory Agents, Non-Steroidal Capsules Drug Carriers Anti-Bacterial Agents Porosity |
Rights: | Copyright status unknown |
DOI: | 10.2217/nnm.11.29 |
Grant ID: | http://purl.org/au-research/grants/arc/LP0989229 |
Published version: | http://dx.doi.org/10.2217/nnm.11.29 |
Appears in Collections: | Aurora harvest 2 Chemical Engineering publications |
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