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https://hdl.handle.net/2440/9824
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Type: | Journal article |
Title: | Zinc protects against arsenic induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity |
Author: | Milton, A. Zalewski, P. Ratnaike, R. |
Citation: | Biometals, 2004; 17(6):707-713 |
Publisher: | Kluwer Academic Publ |
Issue Date: | 2004 |
ISSN: | 0966-0844 1572-8773 |
Statement of Responsibility: | Austin Graham Milton, Peter David Zalewski and Ranjit Nihal Ratnaike |
Abstract: | Acute and chronic arsenic exposure results in toxicity in humans and causes many neurological and other manifestations. For the first time the present study reports that zinc decreases arsenic-induced apoptosis and also confirms a single report of apoptosis induced by arsenic in a neuronal cell line. Apoptosis measured by DEVD-caspase activity peaked between 10 M and 20 M of arsenic trioxide. Higher concentrations of arsenic up to 40 M caused increasing cell death with diminishing DEVD-caspase activity. The beneficial effect of zinc was proportional to its concentration with a significant decrease in arsenic-induced DEVD-caspase activity at 50 M and 75 M zinc (P<0.05). This finding may be of therapeutic benefit in people suffering from chronic exposure to arsenic from natural sources, a global problem especially relevant to millions of people on the Indian subcontinent. |
Keywords: | Neurons Cell Line Animals Mice Arsenicals Oxides Zinc Zinc Sulfate Sodium Oxybate Caspases Enzyme Inhibitors Apoptosis Enzyme Activation Dose-Response Relationship, Drug Phenotype Time Factors Arsenic Trioxide |
Description: | The original publication is available at www.springerlink.com |
DOI: | 10.1007/s10534-004-1210-3 |
Published version: | http://dx.doi.org/10.1007/s10534-004-1210-3 |
Appears in Collections: | Aurora harvest Medicine publications |
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